Brainstem Biomarkers of Clinical Variant and Pathology in Progressive Supranuclear Palsy.

ABSTRACT:

Background

Magnetic resonance brainstem measurements are useful structural biomarkers in the Richardson's syndrome variant of progressive supranuclear palsy (PSP). However, it is unclear how these biomarkers differ across the phenotypic spectrum of PSP and how they relate to underlying pathology.

Objective

The aim of this study was to compare brainstem imaging measures across clinical variants of PSP and determine sensitivity and specificity based on pathologically diagnosed cases.

Methods

A total of 153 patients with PSP who represented eight clinical variants were recruited at Mayo Clinic (Rochester, MN, USA) and underwent structural magnetic resonance imaging (MRI). Midbrain and pons area and superior and middle cerebellar peduncle width measurements were performed

SUBMITTER: Grijalva RM 

PROVIDER: S-EPMC9018485 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature