Escherichia coli induces DNA repair enzymes to protect itself from low-grade hydrogen peroxide stress.
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ABSTRACT: Escherichia coli responds to hydrogen peroxide (H2 O2 ) by inducing defenses that protect H2 O2 -sensitive enzymes. DNA is believed to be another important target of oxidation, and E. coli contains enzymes that can repair oxidative lesions in vitro. However, those enzymes are not known to be induced by H2 O2 , and experiments have indicated that they are not necessary for the cell to withstand natural (low-micromolar) concentrations. In this study, we used H2 O2 -scavenging mutants to impose controlled doses of H2 O2 for extended time. Transcriptomic analysis revealed that in the presence of 1 µM cytoplasmic H2 O2 , the OxyR transcription factor-induced xthA,
SUBMITTER: Gupta A
PROVIDER: S-EPMC9018492 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
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