Statin exposure is associated with reduced development of acute-on-chronic liver failure in a Veterans Affairs cohort.

ABSTRACT:

Backgrounds & aims

There is a need to identify therapies that prevent the development of acute-on-chronic liver failure (ACLF) in patients with cirrhosis. This study sought to evaluate the association between statin exposure and the risk of developing ACLF in a large national cohort of patients with cirrhosis.

Methods

We performed a retrospective cohort study of patients diagnosed with cirrhosis within the Veterans Health Administration from 2008 and 2018. Patients were stratified into 3 groups based on statin exposure (statin naïve, existing statin user, and new statin initiator). Cox proportional hazards regression models with inverse probability treatment weighting and marginal structural models were utilized to comprehensively address potential confounding in estimating

SUBMITTER: Mahmud N 

PROVIDER: S-EPMC9018495 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature