Alcohol use and alcohol use disorder differ in their genetic relationships with PTSD: A genomic structural equation modelling approach.

ABSTRACT:

Purpose

Posttraumatic Stress Disorder (PTSD) is associated with increased alcohol use and alcohol use disorder (AUD), which are all moderately heritable. Studies suggest the genetic association between PTSD and alcohol use differs from that of PTSD and AUD, but further analysis is needed.

Basic procedures

We used genomic Structural Equation Modeling (genomicSEM) to analyze summary statistics from large-scale genome-wide association studies (GWAS) of European Ancestry participants to investigate the genetic relationships between PTSD (both diagnosis and re-experiencing symptom severity) and a range of alcohol use and AUD phenotypes.

Main findings

When we differentiated genetic factors for alcohol use and AUD we observed improved model fit relative to models with all al

SUBMITTER: Bountress KE 

PROVIDER: S-EPMC9018560 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature