The neuroendocrine stress response impairs hippocampal vascular function and memory in male and female rats.

ABSTRACT: Chronic psychological stress affects brain regions involved in memory such as the hippocampus and accelerates age-related cognitive decline, including in Alzheimer's disease and vascular dementia. However, little is known about how chronic stress impacts hippocampal vascular function that is critically involved in maintaining neurocognitive health that could contribute to stress-related memory dysfunction. Here, we used a novel experimental rat model that mimics the neuroendocrine and cardiovascular aspects of chronic stress to determine how the neuroendocrine components of the stress response affect hippocampal function. We studied both male and female rats to determine potential sex differences in the susceptibility of the hippocampus and its vasculature to neuroendocrine stress-induced

SUBMITTER: Johnson AC 

PROVIDER: S-EPMC9018625 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature