Neural correlates and predictors of subjective cognitive decline in patients with Parkinson's disease.

ABSTRACT:

Background

Subjective cognitive decline (SCD) may occur very early in the course of Parkinson's disease (PD) before the onset of objective cognitive decline. Data on neural correlates and determinants of SCD in PD are rare.

Objective

The aim of the present study was to identify neural correlates as well as sociodemographic, clinical, and neuropsychological predictors of SCD in patients with PD.

Methods

We retrospectively analyzed 30 patients with PD without cognitive impairment (23% female, 66.90 ± 7.20 years, UPDRS-III: 19.83 ± 9.29), of which n = 12 patients were classified as having no SCD (control group, PD-CG) and n = 18 as having SCD (PD-SCD). Neuropsychological testing and 18-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) were conducted. SCD was a

SUBMITTER: Ophey A 

PROVIDER: S-EPMC9018636 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature