Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment.

ABSTRACT: Decision-making is a continuous and dynamic process with prior experience reflected in and used by the brain to guide adaptive behavior. However, most neurobiological studies constrain behavior and/or analyses to task-related variables, not accounting for the continuous internal and temporal space in which they occur. We show mice rely on information learned through recent and longer-term experience beyond just prior actions and reward - including checking behavior and the passage of time - to guide self-initiated, self-paced, and self-generated actions. These experiences are represented in secondary motor cortex (M2) activity and its projections into dorsal medial striatum (DMS). M2 integrates this information to bias strategy-level decision-making, and DMS projections reflect specific as

SUBMITTER: Schreiner DC 

PROVIDER: S-EPMC9018678 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature