Epigenetic remodelling of Fxyd1 promoters in developing heart and brain tissues.

ABSTRACT: FXYD1 is a key protein controlling ion channel transport. FXYD1 exerts its function by regulating Na⁺/K⁺-ATPase activity, mainly in brain and cardiac tissues. Alterations of the expression level of the FXYD1 protein cause diastolic dysfunction and arrhythmias in heart and decreased neuronal dendritic tree and spine formation in brain. Moreover, FXYD1, a target of MeCP2, plays a crucial role in the pathogenesis of the Rett syndrome, a neurodevelopmental disorder. Thus, the amount of FXYD1 must be strictly controlled in a tissue specific manner and, likely, during development. Epigenetic modifications, particularly DNA methylation, represent the major candidate mechanism that may regulate Fxyd1 expression. In the present study, we performed a comprehensive DNA methylati

SUBMITTER: Cuomo M 

PROVIDER: S-EPMC9018693 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature