Evidence for postnatal neurogenesis in the human amygdala.

ABSTRACT: The human amygdala is involved in processing of memory, decision-making, and emotional responses. Previous studies suggested that the amygdala may represent a neurogenic niche in mammals. By combining two distinct methodological approaches, lipofuscin quantification and ¹⁴C-based retrospective birth dating of neurons, along with mathematical modelling, we here explored whether postnatal neurogenesis exists in the human amygdala. We investigated post-mortem samples of twelve neurologically healthy subjects. The average rate of lipofuscin-negative neurons was 3.4%, representing a substantial proportion of cells substantially younger than the individual. Mass spectrometry analysis of genomic ¹⁴C-concentrations in amygdala neurons compared with atmospheric ¹⁴C-

SUBMITTER: Roeder SS 

PROVIDER: S-EPMC9018740 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature