Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior.

ABSTRACT: Impairments in identifying and responding to the emotions of others manifest in a variety of psychopathologies. Therefore, elaborating the neurobiological mechanisms that underpin social responses to social emotions, or social affective behavior, is a translationally important goal. The insular cortex is consistently implicated in stress-related social and anxiety disorders, which are associated with diminished ability to make and use inferences about the emotions of others to guide behavior. We investigated how corticotropin-releasing factor (CRF), a neuromodulator evoked upon exposure to stressed conspecifics, influenced the insula. We hypothesized that social affective behavior requires CRF signaling in the insular cortex in order to detect stress in social interactions. In acute slices

SUBMITTER: Rieger NS 

PROVIDER: S-EPMC9018766 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature