A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea.

ABSTRACT: The gut microbiota represents a large community of microorganisms that play an important role in immune regulation and maintenance of homeostasis. Living bacteria receive increasing interest as potential therapeutics for gut disorders, because they inhibit the colonization of pathogens and positively regulate the composition of bacteria in gut. However, these treatments are often accompanied by antibiotic administration targeting pathogens. In these cases, the efficacy of therapeutic bacteria is compromised by their susceptibility to antibiotics. Here, we demonstrate that a single-cell coating composed of tannic acids and ferric ions, referred to as 'nanoarmor', can protect bacteria from the action of antibiotics. The nanoarmor protects both Gram-positive and Gram-negative bacteria against

SUBMITTER: Pan J 

PROVIDER: S-EPMC9019008 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature