Arsenic, cadmium, and selenium exposures and bone mineral density-related endpoints: The HORTEGA study.

ABSTRACT:

Background and objectives

Experimental data suggest that trace elements, such as arsenic (As), cadmium (Cd), and selenium (Se) can influence the bone remodeling process. We evaluated the cross-sectional association between As, Cd, and Se biomarkers with bone mineral density (BMD) measured at the calcaneus, in a representative sample of a general population from Spain. As secondary analyses we evaluated the associations of interest in subgroups defined by well-established BMD determinants, and also conducted prospective analysis of osteoporosis-related incident bone fractures restricted to participants older than 50 years-old.

Methods

In N = 1365 Hortega Study participants >20 years-old, urine As and Cd were measured by inductively coupled-plasma mass spectrometry (ICPMS); pl

SUBMITTER: Galvez-Fernandez M 

PROVIDER: S-EPMC9019194 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature