Kinase inhibitors: look beyond the label on the bottle.

ABSTRACT: The majority of scientists working in the field of cancer experimental therapeutics recognize that many drugs that claim to be "specific" for one target enzyme in fact regulate to varying degrees the activities of other additional protein targets. Some of these targets are known and are recognized as being an essential component of a drug's biology. However, many other targets fall into the category of "unknown unknowns". Thus, the collective therapeutic outcome for almost all clinically relevant drugs is reliant on both the claimed primary and secondary "on" targets as well as some of the unexpected unknown "off" targets. This review discusses the biology of several FDA approved cancer therapeutic drugs whose initial reported targets only represented the tip-of-the-iceberg in terms of how

SUBMITTER: Dent P 

PROVIDER: S-EPMC9019203 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature