Abnormal Vacuole Membrane Protein-1 Expression in Parkinson's Disease Patients.

ABSTRACT:

Background

Parkinson's disease (PD) is pathologically characterized by progressive dopaminergic (DAergic) neuron loss in the substantia nigra pars compacta (SNpc) and accumulation of intracytoplasmic α-synuclein-containing Lewy bodies. Autophagy has been identified as a critical component in the development and progression of PD. Several autophagy genes have been identified as being altered in PD. One of those genes, vacuole membrane protein-1 (VMP1), an autophagy protein localized in the endoplasmic reticulum (ER) in DAergic neurons, has been shown to cause motor disorder, severe loss of DAergic neurons, and autophagy flux disturbance in the VMP1 knockout mouse model.

Objective

To evaluate for the first time the alteration on the expression of the VMP1 gene and its c

SUBMITTER: Al-Nusaif M 

PROVIDER: S-EPMC9019220 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature