Phthalate Exposure, PPARα Variants, and Neurocognitive Development of Children at Two Years.

ABSTRACT: Background: The PPARα gene may be crucial to the neurotoxic effect of phthalates. However, epidemiological studies considering the neurodevelopmental influence of phthalates interacting with genetic susceptibility are limited. We hypothesized phthalates could interact with the PPARα gene, synergistically affecting neurocognitive development. Methods: A total of 961 mother-infant pairs were involved in this study. The concentrations of phthalate metabolites in maternal urine during pregnancy were detected. Children's neurocognitive development was estimated with the Bailey Infant Development Inventory (BSID). Genetic variations in PPARα were genotyped with the Illumina Asian Screening Array. We applied generalized linear regression models to estimate genotypes and phthalate me

SUBMITTER: Yu L 

PROVIDER: S-EPMC9019295 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature