A novel role for GalNAc-T2 dependent glycosylation in energy homeostasis.

ABSTRACT:

Objective

GALNT2, encoding polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2), was initially discovered as a regulator of high-density lipoprotein metabolism. GalNAc-T2 is known to exert these effects through post-translational modification, i.e., O-linked glycosylation of secreted proteins with established roles in plasma lipid metabolism. It has recently become clear that loss of GALNT2 in rodents, cattle, nonhuman primates, and humans should be regarded as a novel congenital disorder of glycosylation that affects development and body weight. The role of GALNT2 in metabolic abnormalities other than plasma lipids, including insulin sensitivity and energy homeostasis, is poorly understood.

Methods

GWAS data from the UK Biobank was used to study variation in the GALN

SUBMITTER: Verzijl CRC 

PROVIDER: S-EPMC9019398 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature