Transplantation of a beating heart: A first in man.

ABSTRACT:

Background

In the current practice, graft ischaemia and reperfusion injury (IRI) is considered an inevitable component in organ transplantation, contributes to compromised organ quality, inferior graft survival and limitations in organ availability. Among all the donor organs, the heart is most vulnerable to IRI and the tolerated ischaemic time is the shortest.

Methods

By combining adapted surgical techniques and normothermic machine perfusion (NMP), we performed the first case of ischaemia-free beating heart transplantation (IFBHT) in man. The donor heart was procured after an in situ NMP circuit was established, then underwent ex situ NMP and implanted under NMP support. The post-transplant graft function was monitored.

Findings

The donor heart was pro

SUBMITTER: Yin S 

PROVIDER: S-EPMC9019404 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature