Effects of exercise on NAFLD using non-targeted metabolomics in adipose tissue, plasma, urine, and stool.

ABSTRACT: The mechanisms by which exercise benefits patients with non-alcoholic fatty liver disease (NAFLD), the most common liver disease worldwide, remain poorly understood. A non-targeted liquid chromatography-mass spectrometry (LC-MS)-based metabolomics analysis was used to identify metabolic changes associated with NAFLD in humans upon exercise intervention (without diet change) across four different sample types-adipose tissue (AT), plasma, urine, and stool. Altogether, 46 subjects with NAFLD participated in this randomized controlled intervention study. The intervention group (n = 21) performed high-intensity interval training (HIIT) for 12 weeks while the control group (n = 25) kept their sedentary lifestyle. The participants' clinical parameters and metabolic profiles were compared between

SUBMITTER: Babu AF 

PROVIDER: S-EPMC9019539 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature