MiR-654-5p Contributes to the Activation and Proliferation of Hepatic Stellate Cells by Targeting RXRα.

ABSTRACT: Liver fibrosis (LF) is a major disease that threatens human health. Hepatic stellate cells (HSCs) contribute directly to LF via extracellular matrix (ECM) secretion. Moreover, RXRα is an important nuclear receptor that plays a key regulatory role in HSC activation. Meanwhile, microRNAs (miRNAs) have been identified as significant regulators of LF development. In particular, miR-654-5p is involved in cellular migration and proliferation, and via bioinformatics analysis, has been identified as a potential factor that targets RXRα in humans and in mice. However, the precise relationship between miR-654-5p and RXRα in the context of LF, remains unknown and is the primary focus of the current study. To establish in vitro activated cell model human primary HSCs were cultured in

SUBMITTER: Ma H 

PROVIDER: S-EPMC9019757 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature