AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery.

ABSTRACT:

Introduction

The portfolio of novel targets to treat Alzheimer's disease (AD) has been enriched by the Accelerating Medicines Partnership Program for Alzheimer's Disease (AMP AD) program.

Methods

Publicly available resources, such as literature and databases, enabled a data-driven effort to identify existing small molecule modulators for many protein products expressed by the genes nominated by AMP AD and suitable positive control compounds to be included in the set. Compounds contained within the set were manually selected and annotated with associated published, predicted, and/or experimental data.

Results

We built an annotated set of 171 small molecule modulators targeting 98 unique proteins that have been nominated by AMP AD consortium members as novel targets for

SUBMITTER: Potjewyd FM 

PROVIDER: S-EPMC9019904 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature