Fuel-driven macromolecular coacervation in complex coacervate core micelles† † Electronic supplementary information (ESI) available. See DOI: 10.1039/d2sc00805j

ABSTRACT: Fuel-driven macromolecular coacervation is an entry into the transient formation of highly charged, responsive material phases. In this work, we used a chemical reaction network (CRN) to drive the coacervation of macromolecular species readily produced using radical polymerisation methods. The CRN enables transient quaternization of tertiary amine substrates, driven by the conversion of electron deficient allyl acetates and thiol or amine nucleophiles. By incorporating tertiary amine functionality into block copolymers, we demonstrate chemical triggered complex coacervate core micelle (C3M) assembly and disassembly. In contrast to most dynamic coacervate systems, this CRN operates at constant physiological pH without the need for complex biomolecules. By varying the allyl acetate fuel, dea

SUBMITTER: Lewis R 

PROVIDER: S-EPMC9019912 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature