Altered voxel-level whole-brain functional connectivity in multiple system atrophy patients with depression symptoms.

ABSTRACT:

Background

It is yet unknown if the whole-brain resting-state network is altered in multiple system atrophy with symptoms of depression. This study aimed to investigate if and how depression symptoms in multiple system atrophy are associated with resting-state network dysfunction.

Methods

We assessed the resting-state functional network matric using Degree centrality (DC) coupling with a second ROI-wise functional connectivity (FC) algorithm in a multimodal imaging case-control study that enrolled 32 multiple system atrophy patients with depression symptoms (MSA-D), 30 multiple system atrophy patients without depression symptoms (MSA-ND), and 34 healthy controls (HC).

Results

Compared to HC, MSA-D showed more extensive DC hub dysfunction in the left precentral and rig

SUBMITTER: Yang HG 

PROVIDER: S-EPMC9020004 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature