PTHrP induces STAT5 activation, secretory differentiation and accelerates mammary tumor development.

ABSTRACT:

Background

Parathyroid hormone-related protein (PTHrP) is required for embryonic breast development and has important functions during lactation, when it is produced by alveolar epithelial cells and secreted into the maternal circulation to mobilize skeletal calcium used for milk production. PTHrP is also produced by breast cancers, and GWAS studies suggest that it influences breast cancer risk. However, the exact functions of PTHrP in breast cancer biology remain unsettled.

Methods

We developed a tetracycline-regulated, MMTV (mouse mammary tumor virus)-driven model of PTHrP overexpression in mammary epithelial cells (Tet-PTHrP mice) and bred these mice with the MMTV-PyMT (polyoma middle tumor-antigen) breast cancer model to analyze the impact of PTHrP overexpression on norm

SUBMITTER: Grinman DY 

PROVIDER: S-EPMC9020078 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature