Total synthesis of himastatin.

ABSTRACT: The natural product himastatin has an unusual homodimeric structure that presents a substantial synthetic challenge. We report the concise total synthesis of himastatin from readily accessible precursors, incorporating a final-stage dimerization strategy that was inspired by a detailed consideration of the compound's biogenesis. Combining this approach with a modular synthesis enabled expedient access to more than a dozen designed derivatives of himastatin, including synthetic probes that provide insight into its antibiotic activity.

SUBMITTER: D'Angelo KA 

PROVIDER: S-EPMC9020136 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature