Exhaled nitric oxide in early rheumatoid arthritis and effects of methotrexate treatment.

ABSTRACT: Patients with established rheumatoid arthritis (RA) and disease modifying treatments have lower nitric oxide (NO) levels in the alveolar compartment (C_ANO) and in the airway wall (C_awNO), but also higher diffusion capacities for NO in the airways (D_awNO) compared to matched controls. The aim of the present study was to investigate the NO lung dynamics in patients with recent onset RA before and after immune suppression with methotrexate therapy. Patients with early RA and antibodies against anticitrullinated peptides (ACPA) were recruited. Measurement of exhaled NO and inflammatory markers in serum were performed. Clinical disease activity was evaluated with Disease Activity Score for 28 joints. Healthy individuals were used as matched controls. Data are pr

SUBMITTER: Weitoft T 

PROVIDER: S-EPMC9020158 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature