Identification of Drug Interaction Adverse Events in Patients With COVID-19: A Systematic Review.

ABSTRACT:

Importance

During the COVID-19 pandemic, urgent clinical management of patients has mainly included drugs currently administered for other diseases, referred to as repositioned drugs. As a result, some of these drugs have proved to be not only ineffective but also harmful because of adverse events associated with drug-drug interactions (DDIs).

Objective

To identify DDIs that led to adverse clinical outcomes and/or adverse drug reactions in patients with COVID-19 by systematically reviewing the literature and assessing the value of drug interaction checkers in identifying such events.

Evidence review

After identification of the drugs used during the COVID-19 pandemic, the drug interaction checkers Drugs.com, COVID-19 Drug Interactions, LexiComp, Medscape, and WebMD wer

SUBMITTER: Conti V 

PROVIDER: S-EPMC9020212 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature