Association of Familial Hypercholesterolemia and Statin Use With Risk of Dementia in Norway.

ABSTRACT:

Importance

Hypercholesterolemia, which is a cardiovascular risk factor, may also be associated with dementia risk. The benefit of statin treatment on dementia risk is controversial.

Objective

To determine whether individuals with familial hypercholesterolemia (FH), who have been exposed to lifelong hypercholesterolemia, have an excess risk of dementia and whether statin use is associated with dementia risk.

Design, setting, and participants

This was a prospective cohort study performed from 2008 to 2018 in Norway. Statistical analysis was performed from January 2021 to February 2022. This study included individuals with genetically verified FH and age-matched and sex-matched controls obtained from the general Norwegian population.

Exposures

Dementia was defined

SUBMITTER: Mundal LJ 

PROVIDER: S-EPMC9020214 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature