Topical Application of Tetrandrine Nanoemulsion Promotes the Expansion of CD4⁺Foxp3⁺ Regulatory T Cells and Alleviates Imiquimod-Induced Psoriasis in Mice.

ABSTRACT: There is compelling evidence that CD4⁺Foxp3⁺ regulatory T cells (Tregs) are indispensable in the inhibition of autoimmune inflammatory responses, including psoriasis. Recently, we showed that systemically treatment with tetrandrine (TET), a two-pore channel inhibitor identified from the Chinese herb Stephania tetrandra S. Moor, could promote the proliferative expansion of Tregs in mice through stimulation of TNF-TNFR2 interaction. We thus hypothesized that topical administration of TET might also expand Tregs and consequently inhibit psoriasis. To this end, we developed a TET nanoemulsion and examined its effect on the expansion of Tregs after topical administration on mouse psoriasis induced by imiquimod. The result of our experiment showed that topical treatm

SUBMITTER: Chen S 

PROVIDER: S-EPMC9020220 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature