Epidemiology of atypical parkinsonian syndromes.

ABSTRACT: Atypical parkinsonism or atypical parkinsonian syndromes (APS) refer to a group of neurodegenerative disorders which mimic typical Parkinson's disease but poorly respond to levodopa treatment and deteriorate faster. APS are very rare and among them, progressive supranuclear palsy (PSP), multiple system atrophy (MSA), and corticobasal degeneration (CBD) are the three relatively better characterized entities. The prevalence estimates of PSP, MSA, or CBD are mostly <10/10⁵, and the incidence estimates are around 1/10⁵ person-year; both estimates remain stable over the past few decades. The age at onset is relatively young for MSA at late 50s, followed by CBD at early 60s, and then PSP at late 60s. The gender difference is not significant in APS, although slight female pr

SUBMITTER: Lo RY 

PROVIDER: S-EPMC9020244 | biostudies-literature | 2022 Apr-Jun

REPOSITORIES: biostudies-literature