Renal safety evaluation of aspirin plus edaravone in patients with ischaemic stroke: a retrospective cohort study.

ABSTRACT:

Background and objective

Aspirin combined with edaravone is more effective than aspirin or edaravone alone in the treatment of ischaemic stroke. Aspirin is defined as a nephrotoxic drug while the renal safety of edaravone is controversial. We aimed to evaluate whether edaravone will increase the nephrotoxicity of aspirin in patients with ischaemic stroke.

Design

A propensity score-matched retrospective cohort study.

Setting

A tertiary hospital in China.

Participants

Patients with ischaemic stroke were treated with aspirin from February 2007 to May 2018.

Primary and secondary outcome measures

Acute kidney injury (AKI, diagnosed by the Acute Kidney Injury Network), decreased estimated glomerular filtration rate (eGFR,>10%), gastrointestinal bleeding and in

SUBMITTER: Yang HQ 

PROVIDER: S-EPMC9020313 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature