Liver kinase B1 rs9282860 polymorphism and risk for multiple sclerosis in White and Black Americans.

ABSTRACT:

Background

We previously reported that the single nucleotide polymorphism (SNP) rs9282860 in serine threonine kinase 11 (STK11) gene which codes for liver kinase B1 (LKB1) has higher prevalence in White relapsing-remitting multiple sclerosis (RRMS) patients than controls. However it is not known if this SNP is a risk factor for MS in other populations.

Methods

We assessed the prevalence of the STK11 SNP in samples collected from African American (AA) persons with MS (PwMS) and controls at multiple Veterans Affairs (VA) Medical Centers and from a network of academic MS centers. Genotyping was carried out using a specific Taqman assay. Comparisons of SNP frequencies were made using Fisher's exact test to determine significance and odds ratios. Group means were compared by appr

SUBMITTER: Boullerne AI 

PROVIDER: S-EPMC9020467 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature