Time dependent decline of neutralizing antibody titers in COVID-19 patients from Pune, India and evidence of reinfection.

ABSTRACT:

Purpose

To assess modulation of neutralizing antibody titers in COVID-19 patients and understand association of variables such as age, presence of comorbidity, BMI and gender with antibody titers.

Methods

Patients (n = 100) diagnosed from 20th March 2020 to 17th August 2020 and treated at two large hospitals from Pune, India were included and followed up (clinical and serologic) for varied periods. IgG-anti-SARS-CoV-2 (Spike protein-based ELISA) and neutralizing antibody titers (NAb, PRNT) were determined in all the samples.

Results

Of the 100 patients enrolled initially (median 60 days of diagnosis), follow up samples were collected from 70 patients (median 106 days of diagnosis). Overall, NAb titers reduced significantly (p < 0.001) and as early as 3-4 months. Durin

SUBMITTER: Doke P 

PROVIDER: S-EPMC9020493 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature