Early Atherosclerotic Inflammatory Pathways in Children with Obstructive Sleep Apnea.

ABSTRACT:

Objective

To evaluate structural and functional carotid changes and inflammatory profiles in children with obstructive sleep apnea (OSA) and healthy controls.

Study design

Patients with OSA and matched controls (ages 5-13 years) were recruited. Proinflammatory cytokines and acute phase reactants were measured at 6:00 p.m. Common carotid artery measures were determined using ultrasound. Confirmatory factor analysis was used to determine subgroups of cytokines and their effects on carotid measures.

Results

Ninety-six patients participated (53 healthy controls, 43 patients with OSA). OSA was associated with increased proinflammatory cytokines (cluster of differentiation-40 ligand [CD40-L], interleukin [IL]-6, and IL-8) and high sensitivity C-reactive protein (P < .05 for

SUBMITTER: Smith DF 

PROVIDER: S-EPMC9020582 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature