A discrete neuronal population coordinates brain-wide developmental activity.

ABSTRACT: In vertebrates, stimulus-independent activity accompanies neural circuit maturation throughout the developing brain^1,2. The recent discovery of similar activity in the developing Drosophila central nervous system suggests that developmental activity is fundamental to the assembly of complex brains³. How such activity is coordinated across disparate brain regions to influence synaptic development at the level of defined cell types is not well understood. Here we show that neurons expressing the cation channel transient receptor potential gamma (Trpγ) relay and pattern developmental activity throughout the Drosophila brain. In trpγ mutants, activity is attenuated globally, and both patterns of activity and synapse structure are altered in a cell-type-specific manner. Le

SUBMITTER: Bajar BT 

PROVIDER: S-EPMC9020639 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature