Customized low-cost high-throughput amplifier for electro-fluidic detection of cell volume changes in point-of-care applications.

ABSTRACT: Physical parameters of the pathogenic cells, like its volume, shape, and stiffness, are important biomarkers for diseases, chemical changes within the cell, and overall cell health. The response of pathogenic bacteria and viruses to different chemical disinfectants is studied widely. Some of the routinely employed techniques to measure these changes require elaborate and expensive equipment which limits any study to a non-mobile research lab facility. Recently, we showed a micropore-based electro-fluidic technique to have great promise in measuring subtle changes in cell volumes at high throughput and resolution. This method, however, requires commercial amplifiers, which makes this technique expensive and incompatible for in-field use. In this paper, we develop a home-built amplifier to m

SUBMITTER: Kaushik S 

PROVIDER: S-EPMC9020695 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature