Identification of bipotent progenitors that give rise to myogenic and connective tissues in mouse.

ABSTRACT: How distinct cell fates are manifested by direct lineage ancestry from bipotent progenitors, or by specification of individual cell types is a key question for understanding the emergence of tissues. The interplay between skeletal muscle progenitors and associated connective tissue cells provides a model for examining how muscle functional units are established. Most craniofacial structures originate from the vertebrate-specific neural crest cells except in the dorsal portion of the head, where they arise from cranial mesoderm. Here, using multiple lineage-tracing strategies combined with single cell RNAseq and in situ analyses, we identify bipotent progenitors expressing Myf5 (an upstream regulator of myogenic fate) that give rise to both muscle and juxtaposed connective tissue. Fo

SUBMITTER: Grimaldi A 

PROVIDER: S-EPMC9020825 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature