Dataset Information

Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials.

ABSTRACT:

Objective

To assess the clinical efficacy of flavonoid supplements on allergic diseases.

Design

Systematic review. Data Sources. MEDLINE/PubMed, Scopus, Web of Science, and Embase databases were searched from inception to September 2021. Eligibility Criteria for Selecting Studies. Eligible study designs were randomized controlled trials that investigated the effect of flavonoids applied to allergic diseases.

Results

This review included 15 randomized controlled trials, including allergic rhinitis/cedar pollinosis (n = 10), asthma (n = 3), and atopic dermatitis (n = 2). A total of 990 participants aged 6 to 69 years were included in these studies. Globally, 12 studies (80%) revealed some benefits of flavonoids (isolate or combined with other compounds) in allergic patients, while three studies (20%) reported no statistically significant impact on symptom scores and/or lung function. No severe adverse events related to treatment were reported. According to the GRADE system, the outcomes evaluated were of low to moderate quality of evidence.

Conclusions

Overall, this review suggests that the administration of flavonoids may provide a viable strategy for mitigating allergic symptoms. Future trials with high methodological quality are needed to establish definitive conclusions. This trial is registered with PROSPERO registration no. CRD42021237403.

SUBMITTER: de Almeida Brasiel PG

PROVIDER: S-EPMC9020920 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials.

de Almeida Brasiel Poliana Guiomar PG Guimarães Fernanda Verdini FV Rodrigues Patrícia Machado PM Bou-Habib Dumith Chequer DC Carvalho Vinicius de Frias VF

Journal of immunology research 20220413

<h4>Objective</h4>To assess the clinical efficacy of flavonoid supplements on allergic diseases.<h4>Design</h4>Systematic review. <i>Data Sources</i>. MEDLINE/PubMed, Scopus, Web of Science, and Embase databases were searched from inception to September 2021. <i>Eligibility Criteria for Selecting Studies</i>. Eligible study designs were randomized controlled trials that investigated the effect of flavonoids applied to allergic diseases.<h4>Results</h4>This review included 15 randomized controlle ...[more]

PMID: 35465348

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Project description:In 2012, the United States Food and Drug Administration (FDA) issued a warning regarding potential adverse effects of HMG-CoA reductase inhibitors (statins) on cognition, based on the Adverse Events Reporting System and a review of the medical literature. We aimed to synthesize randomized clinical trial (RCTs) evidence on the association between statin therapy and cognitive outcomes.We searched MEDLINE, EMBASE, and Cochrane CENTRAL through December 2012, and reviewed published systematic reviews of statin treatment. We sought RCTs that compared statin treatment versus placebo or standard care, and reported at least one cognitive outcome (frequency of adverse cognitive events or measurements using standard neuropsychological cognitive test scores). Studies reporting sufficient information to calculate effect sizes were included in meta-analyses. Standardized and unstandardized mean differences were calculated for continuous outcomes for global cognition and for pre-specified cognitive domains. The main outcome was change in cognition measured by neuropsychological tests; an outcome of secondary interest was the frequency of adverse cognitive events observed during follow-up.We identified 25 RCTs (all placebo-controlled) reporting cognitive outcomes in 46,836 subjects, of which 23 RCTs reported cognitive test results in 29,012 participants. Adverse cognitive outcomes attributable to statins were rarely reported in trials involving cognitively normal or impaired subjects. Furthermore, meta-analysis of cognitive test data (14 studies; 27,643 participants) failed to show significant adverse effects of statins on all tests of cognition in either cognitively normal subjects (standardized mean difference 0.01, 95% confidence interval, CI, -0.01 to 0.03, p?=?0.42) or Alzheimer's disease subjects (standardized mean difference -0.05, 95% CI -0.19 to 0.10, p?=?0.38).Statin therapy was not associated with cognitive impairment in RCTs. These results raise questions regarding the continued merit of the FDA warning about potential adverse effects of statins on cognition.

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Dataset Information

Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials.

Objective

Design

Results

Conclusions

Publications

Therapeutic Efficacy of Flavonoids in Allergies: A Systematic Review of Randomized Controlled Trials.

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