Structural Effects of pH Variation and Calcium Amount on the Microencapsulation of Glutathione in Alginate Polymers.

ABSTRACT: Reduced glutathione (GSH) has a high antioxidant capacity and is present in nearly every cell in the body, playing important roles in nutrient metabolism, antioxidant defense, and regulation of cellular events. Conversely, alginate is a macromolecule that has been widely used in the food, pharmaceutical, biomedical, and textile industries due to its biocompatibility, biodegradability, nontoxicity, and nonimmunogenicity as well as for its capabilities of retaining water and stabilizing emulsions. The primary goal of this study was to characterize and optimize the formation of a molecular complex of calcium alginate with GSH using a computational approach. As methods, we evaluated the influence of varying the amount of calcium cations at two different pHs on the structural stability of Ca

SUBMITTER: Bustos D 

PROVIDER: S-EPMC9020975 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature