SARS-CoV-2 vaccination can elicit a CD8 T-cell dominant hepatitis.

ABSTRACT:

Background & aims

Autoimmune hepatitis episodes have been described following SARS-CoV-2 infection and vaccination but their pathophysiology remains unclear. Herein, we report the case of a 52-year-old male, presenting with bimodal episodes of acute hepatitis, each occurring 2-3 weeks after BNT162b2 mRNA vaccination. We sought to identify the underlying immune correlates. The patient received oral budesonide, relapsed, but achieved remission under systemic steroids.

Methods

Imaging mass cytometry for spatial immune profiling was performed on liver biopsy tissue. Flow cytometry was performed to dissect CD8 T-cell phenotypes and identify SARS-CoV-2-specific and EBV-specific T cells longitudinally. Vaccine-induced antibodies were determined by ELISA. Data were correlated with c

SUBMITTER: Boettler T 

PROVIDER: S-EPMC9021033 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature