Sleep-disordered breathing-related symptoms and risk of stroke: cohort study and Mendelian randomization analysis.

ABSTRACT:

Background

Sleep-disordered breathing (SDB) may contribute to development of stroke. However, findings are inconclusive. We investigated whether SDB-related symptoms are associated with incidence of stroke and its types in a general community sample of adult men and women as well as to perform Mendelian randomization (MR) analysis.

Methods

We used data from a cohort of 41,742 Swedish adults (56-94 years of age) who completed questionnaires regarding snoring, cessation of breathing, lifestyle and health characteristics. Participants were followed up for incident stroke and death over 8 years through linkage to the Swedish Registers. Hazard ratios, adjusted for potential confounders, were estimated by Cox proportional hazards regression. MR analyses were performed using single

SUBMITTER: Titova OE 

PROVIDER: S-EPMC9021054 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature