Mitochondrial oxidative phosphorylation is dispensable for survival of CD34⁺ chronic myeloid leukemia stem and progenitor cells.

ABSTRACT: Chronic myeloid leukemia (CML) are initiated and sustained by self-renewing malignant CD34⁺ stem cells. Extensive efforts have been made to reveal the metabolic signature of the leukemia stem/progenitor cells in genomic, transcriptomic, and metabolomic studies. However, very little proteomic investigation has been conducted and the mechanism regarding at what level the metabolic program was rewired remains poorly understood. Here, using label-free quantitative proteomic profiling, we compared the signature of CD34⁺ stem/progenitor cells collected from CML individuals with that of healthy donors and observed significant changes in the abundance of enzymes associated with aerobic central carbonate metabolic pathways. Specifically, CML stem/progenitor cells expressed inc

SUBMITTER: Yan JS 

PROVIDER: S-EPMC9021200 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature