Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa.

ABSTRACT: Synaptic loss, neuronal death, and circuit remodeling are common features of central nervous system neurodegenerative disorders. Retinitis pigmentosa (RP), the leading cause of inherited blindness, is a group of retinal dystrophies characterized by photoreceptor dysfunction and death. The insulin receptor, a key controller of metabolism, also regulates neuronal survival and synaptic formation, maintenance, and activity. Indeed, deficient insulin receptor signaling has been implicated in several brain neurodegenerative pathologies. We present evidence linking impaired insulin receptor signaling with RP. We describe a selective decrease in the levels of the insulin receptor and its downstream effector phospho-S6 in retinal horizontal cell terminals in the rd10 mouse model of RP, as well as a

SUBMITTER: Sanchez-Cruz A 

PROVIDER: S-EPMC9021205 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature