Ontology highlight
ABSTRACT:
SUBMITTER: Trouillet AC
PROVIDER: S-EPMC9021208 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Trouillet Anne-Charlotte AC Ducroq Suzanne S Naulé Lydie L Capela Daphné D Parmentier Caroline C Radovick Sally S Hardin-Pouzet Hélène H Mhaouty-Kodja Sakina S
Communications biology 20220420 1
Estrogen receptor (ER) α is involved in several estrogen-modulated neural and peripheral functions. To determine its role in the expression of female and male reproductive behavior, a mouse line lacking the ERα in the nervous system was generated. Mutant females did not exhibit sexual behavior despite normal olfactory preference, and had a reduced number of progesterone receptor-immunoreactive neurons in the ventromedial hypothalamus. Mutant males displayed a moderately impaired sexual behavior ...[more]