Investigation of breast cancer microstructure and microvasculature from time-dependent DWI and CEST in correlation with histological biomarkers.

ABSTRACT: We investigated the associations of time-dependent DWI, non-Gaussian DWI, and CEST parameters with histological biomarkers in a breast cancer xenograft model. 22 xenograft mice (7 MCF-7 and 15 MDA-MB-231) were scanned at 4 diffusion times [T_d = 2.5/5 ms with 11 b-values (0-600 s/mm²) and T_d = 9/27.6 ms with 17 b-values (0-3000 s/mm²), respectively]. The apparent diffusion coefficient (ADC) was estimated using 2 b-values in different combinations (ADC^0-600 using b = 0 and 600 s/mm² and shifted ADC [sADC^200-1500] using b = 200 and 1500 s/mm²) at each of those diffusion times. Then the change (Δ) in ADC/sADC between diffusion times was evaluated. Non-Gaussian diffusion and intravoxel incoherent motion (IVI

SUBMITTER: Someya Y 

PROVIDER: S-EPMC9021220 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature