When inflammation meets lung development-an update on the pathogenesis of bronchopulmonary dysplasia.

ABSTRACT: Even more than 50 years after its initial description, bronchopulmonary dysplasia (BPD) remains one of the most important and lifelong sequelae following premature birth. Tremendous efforts have been undertaken since then to reduce this ever-increasing disease burden but a therapeutic breakthrough preventing BPD is still not in sight. The inflammatory response provoked in the immature lung is a key driver of distorted lung development and impacts the formation of alveolar, mesenchymal, and vascular structures during a particularly vulnerable time-period. During the last 5 years, new scientific insights have led to an improved pathomechanistic understanding of BPD origins and disease drivers. Within the framework of current scientific progress, concepts involving disruption of the balance o

SUBMITTER: Holzfurtner L 

PROVIDER: S-EPMC9021337 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature