Lysophosphatidic Acid Receptor 3 Suppress Neutrophil Extracellular Traps Production and Thrombosis During Sepsis.

ABSTRACT: Sepsis consists of life-threatening organ dysfunction resulting from a dysregulated response to infection. Recent studies have found that excessive neutrophil extracellular traps (NETs) contribute to the pathogenesis of sepsis, thereby increasing morbidity and mortality. Lysophosphatidic acid (LPA) is a small glycerophospholipid molecule that exerts multiple functions by binding to its receptors. Although LPA has been functionally identified to induce NETs, whether and how LPA receptors, especially lysophosphatidic acid receptor 3 (LPA₃), play a role in the development of sepsis has never been explored. A comprehensive understanding of the impact of LPA₃ on sepsis is essential for the development of medical therapy. After intraperitoneal injection of lipopolysaccharid

SUBMITTER: Pei S 

PROVIDER: S-EPMC9021375 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature