RNA Editing-Associated Post-Transcriptional Gene Regulation in Rheumatoid Arthritis.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is an autoimmune disease characterised by systemic inflammation of joints. The observed complexity of RA pathogenesis and studies that have been carried out so far indicate that RA pathogenesis is regulated at multiple levels. Given the role of RNA editing in autoimmune disease, we hypothesised that RNA editing could contribute to RA pathogenesis by regulating gene expression through post-transcriptional mechanisms.

Methods

We identified RNA editing events in synovial tissues from early and established RA compared with normal subjects from an available transcriptome data set using REDItools. To investigate the potential effect of these RNA editing events on gene expression, we carried out an analysis of differential exon usage in the vici

SUBMITTER: Ghanekar Y 

PROVIDER: S-EPMC9021465 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature