A randomised controlled trial of non-invasive ventilation compared with extracorporeal carbon dioxide removal for acute hypercapnic exacerbations of chronic obstructive pulmonary disease.

ABSTRACT:

Background

Patients presenting with acute hypercapnic respiratory failure due to exacerbations of chronic obstructive pulmonary disease (AECOPD) are typically managed with non-invasive ventilation (NIV). The impact of low-flow extracorporeal carbon dioxide removal (ECCO₂R) on outcome in these patients has not been explored in randomised trials.

Methods

Open-label randomised trial comparing NIV (NIV arm) with ECCO₂R (ECCO₂R arm) in patients with AECOPD at high risk of NIV failure (pH < 7.30 after ≥ 1 h of NIV). The primary endpoint was time to cessation of NIV. Secondary outcomes included device tolerance and complications, changes in arterial blood gases, hospital survival.

Results

Eighteen patients (median age 67.5, IQR (61.5-71) year

SUBMITTER: Barrett NA 

PROVIDER: S-EPMC9021560 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature