Weight Changes in Type 2 Diabetes and Cancer Risk: A Latent Class Trajectory Model Study.

ABSTRACT:

Introduction

Body mass index (BMI) is often elevated at type 2 diabetes (T2D) diagnosis. Using latent class trajectory modelling (LCTM) of BMI, we examined whether weight loss after diagnosis influenced cancer incidence and all-cause mortality.

Methods

From 1995 to 2010, we identified 7,708 patients with T2D from the Salford Integrated Record database (UK) and linked to the cancer registry for information on obesity-related cancer (ORC), non-ORC; and all-cause mortality. Repeated BMIs were used to construct sex-specific latent class trajectories. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models.

Results

Four sex-specific BMI classes were identified; stable-overweight, stable-obese, obese-slightly-decreasing, and obese-s

SUBMITTER: Jensen BW 

PROVIDER: S-EPMC9021620 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature