Thyroid Disease and Hepatocellular Carcinoma Survival: A Danish Nationwide Cohort Study.

ABSTRACT:

Introduction

Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer mortality worldwide. Recent animal studies suggest that thyroid hormone treatment improves HCC prognosis. The aim of this study was to describe the association between thyroid disease and HCC prognosis in humans.

Methods

We performed a nationwide cohort study including all persons with an HCC diagnosis from 2000 to 2018. Patients' age, sex, HCC treatment, and diagnoses of thyrotoxicosis, nontoxic goiter, and myxedema were obtained from Danish national healthcare registries. We used regression models to examine the association between thyroid disease and mortality hazard and restricted mean survival time after HCC diagnosis, adjusting for confounding by sex and age.

Results

We included 4,

SUBMITTER: Kornerup LS 

PROVIDER: S-EPMC9021622 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature